Coming to Light tells the dramatic story of Curtis' life, the creation of his monumental work, and his changing views of the people he set out to document. The film also gives Indian people a voice in the discussion of Curtis' images. Hopi, Navajo, Eskimo, Blackfeet, Crow, Blood, Piegan, Suquamish, and Kwakiutl people who are descended from Curtis subjects or who are using his photographs for cultural preservation respond to the pictures, tell stories about the people in the photographs, and discuss the meaning of the images.